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Cat No. | Product Name | Synonyms | Targets |
---|---|---|---|
T1767 | BMH-21 | BMH21 | DNA/RNA Synthesis |
BMH-21, a small molecule DNA intercalator, binds ribosomal DNA and inhibits RNA polymerase I (Pol I) transcription and not affects phosphorylation of H2AX. | |||
T6S0139 | Neobavaisoflavone | Apoptosis , DNA/RNA Synthesis | |
1. Neobavaisoflavone is isolated as a DNA polymerase inhibitor. 2. Neobavaisoflavone might be a potential anabolic agent to treat bone loss-associated diseases. 3. Neobavaisoflavone has anti-inflammatory activity, can si... | |||
T3489 | Dasabuvir | ABT-333 | HCV Protease |
Dasabuvir (ABT-333) is a non-nucleoside inhibitor of the hepatitis C virus (HCV) non-structural protein 5B (NS5B), an RNA-dependent RNA polymerase, with potential activity against HCV. Upon administration and after intra... | |||
T4686 | Simeprevir | TMC435,TMC-435350,Olysio | HCV Protease , SARS-CoV |
Simeprevir (TMC435) is a potent HCV NS3/4A protease inhibitor, and inhibits HCV replication with EC50 of 8 nM. | |||
T6446 | Clevudine | L-FMAU,Levovir | HBV , DNA/RNA Synthesis |
Clevudine (Levovir) is a synthetic pyrimidine analogue with activity against hepatitis B virus (HBV). Intracellularly, clevudine is phosphorylated to its active metabolites, clevudine monophosphate and triphosphate. The ... | |||
T0220 | Foscarnet sodium | Phosphonoformate | Virus Protease , Reverse Transcriptase , DNA/RNA Synthesis |
Foscarnet sodium (Phosphonoformate) is an antiviral agent used in the treatment of cytomegalovirus retinitis. Foscarnet also shows activity against human herpesviruses and HIV. | |||
T6729 | Lomibuvir | VX-222,VCH-222 | HCV Protease |
Lomibuvir (VCH-222) (VX-222) is a selective, non-nucleoside allosteric inhibitor of HCV NS5B polymerase (RdRp) with a Kd of 17 nM. Lomibuvir inhibits the 1b/Con1 HCV subgenomic replicon with an EC 50 of 5.2 nM. Lomibuvir... | |||
T8972 | FIT-039 | Others , DNA/RNA Synthesis , CDK , HSV | |
FIT-039 is a selective and ATP-competitive, orally active inhibitor of CDK9( IC50 : 5.8 μM;CDK9/cyclin T1). FIT-039 inhibits replication of HSV-1 (IC50 of 0.69 μM), HSV-2, human adenovirus, and human CMV. FIT-039 is a pr... | |||
T6194 | Fidaxomicin | Tiacumicin B,OPT-80,Clostomicin B1,PAR-101 | Apoptosis , DNA/RNA Synthesis , Antibacterial , Antibiotic |
Fidaxomicin (Tiacumicin B) is a semisynthetic macrolide antibiotic used to treat Clostridium difficile-associated diarrhea in adults. Fidaxomicin has minimal systemic absorption and has not been linked to serum enzyme el... | |||
T10104 | 3,4-Dihydroxybenzylamine hydrobromide | NSC 263475 hydrobromide | Others , DNA/RNA Synthesis |
3,4-Dihydroxybenzylamine hydrobromide (NSC-263475 hydrobromide) inhibits DNA polymerase activity in melanoma cells and displays growth inhibitory activity in melanoma cell lines with varying degrees of tyrosinase activit... | |||
T8841 | IMT1 | Propanamide, N,N-dimethyl-2-[[4-(2-methylphenyl)-2-oxo-2H-1-benzopyran-7-yl]oxy]-,LDC195943(IMT1) | Others , DNA/RNA Synthesis , Mitochondrial Metabolism |
IMT1 (Propanamide, N,N-dimethyl-2-[[4-(2-methylphenyl)-2-oxo-2H-1-benzopyran-7-yl]oxy]-) has anticancer activity. | |||
T0964 | Floxuridine | 5-Fluorouracil 2'-deoxyriboside,FUDR,Deoxyfluorouridine,NSC 27640 | Apoptosis , Nucleoside Antimetabolite/Analog , Others , DNA/RNA Synthesis , Antibacterial , HSV |
Floxuridine (FUDR) is an antimetabolite, floxuridine inhibits thymidylate synthase, resulting in disruption of DNA synthesis and cytotoxicity. | |||
T8842 | IMT1B | 3-Piperidinecarboxylic acid, 1-[(2R)-2-[[4-(2-chloro-4-fluorophenyl)-2-oxo-2H-1-benzopyran-7-yl]oxy]-1-oxopropyl]-, (3S)-,LDC203974 | Others , DNA/RNA Synthesis |
IMT1B (LDC203974) is an orally administered, specific noncompetitive allosteric inhibitor of the mitochondrial RNA polymerase (POLRMT), effectively suppressing mitochondrial DNA (mtDNA) expression. This action confers it... | |||
T3376 | Cynaroside | Luteoloside,Luteolin 7-β-D-Glucopyranoside,Luteolin 7-O-Glucoside,Luteolin 7-O-β-D-glucoside,Luteolin 7-glucoside | Others , Influenza Virus , DNA/RNA Synthesis |
Cynaroside (Luteolin 7-O-Glucoside) is a flavone, a flavonoid-like chemical compound. It has an anti-oxidant effect, inhibiting lipid and protein oxidation. | |||
T10493 | Beclabuvir | BMS-791325 | Others |
Beclabuvir is an allosteric inhibitor that binds to thumb site 1 of the HCV NS5B RNA-dependent RNA polymerase. It inhibits recombinant NS5B proteins from HCV genotypes 1, 3, 4, and 5 (IC50 < 28 nM). | |||
T9051 | ZYN57939 | MTR-106 | DNA/RNA Synthesis |
ZYN57939 (MTR-106) is RNA polymerase I inhibitor for treating RNA polymerase I- mediated diseases. ZYN57939 showed inhibitory activity with IC50 of 0.855 μM against human HT- 29 cancer cell lines. | |||
T6833 | Favipiravir | T-705,6-Fluoro-3-oxo-3,4-dihydropyrazine-2-carboxamide | Others , SARS-CoV , Influenza Virus , DNA/RNA Synthesis |
Favipiravir (T-705) (T-705), an effective and selective RNA-dependent RNA polymerase inhibitor, are applied to treat influenza virus infections. | |||
T27696 | JTK-109 | JTK109 | HCV Protease |
JTK-109 is an inhibitor of hepatitis C virus NS5B RNA-dependent RNA polymerase inhibitor and inhibits G1b and G3a subgenomic replicons and recombinant enzymes. | |||
TNU0442 | 2’-beta-C-Methyl inosine | 2'-C-Methylinosine | Antiviral , DNA/RNA Synthesis |
2'-beta-C-Methyl inosine (2'-C-Methylinosine) is an HCV RNA polymerase inhibitor with antiviral activity that has been investigated for the treatment of Hepatitis C Virus infections. ccc_R08 is an inhibitor of HCV RNA po... | |||
T16710 | Mericitabine | R-7128,RG 7128,PSI 6130 diisobutyrate | HCV Protease |
Mericitabine (R-7128) is a nucleoside HCV NS5B polymerase inhibitor. It acts as an RNA chain terminator and prevents the elongation of RNA transcripts during replication. |